Head coach Mike Smith has ruled out guard Justin Blalock (back) and wide receiver Harry Douglas (foot) for Sunday's game at New York, as the two were not able to practice at all this week.
Blalock will be missing his first start in 102 games as the longest current streak among Falcons comes to an end. The likely replacement for Blalock in Sunday's game is Harland Gunn, who played in three games in 2013 and started 2014 on the team's practice squad.
Douglas will be missing his second straight game with a foot injury suffered in the Week 3 win over Tampa Bay.
WR Devin Hester, WR Julio Jones, S Kemal Ishmael and LB Prince Shembo, all part of the Week 5 injury report, are listed as probable for Sunday.
