The Falcons will be without RB Tevin Coleman, DE Dwight Freeney and TE Jacob Tamme on Thursday night when they take on the Tampa Bay Buccaneers.
Coleman injured his hamstring in Atlanta's Week 7 contest against the San Diego Chargers, and has been unable to practice since.
The Falcons rely heavily on Coleman's explosive style of running, and as of Tuesday, head coach Dan Quinn said it was still in question.
Freeney (quad) and Tamme (shoulder) both left Sunday's game against the Packers with injuries, and both will be sidelined at Raymond James Stadium.